Proto-Oncogene Proteins c-met

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.

Also Known As:

MET Proto-Oncogene, Receptor Tyrosine Kinase; MET Receptor Tyrosine Kinase; Receptor, HGF; Receptor, Hepatocyte Growth Factor; Receptor, Scatter Factor; Scatter Factor Receptor; c-Met Receptor Tyrosine Kinase; MET Proto Oncogene, Receptor Tyrosine Kinase; Proto Oncogene Proteins c met; Proto-Oncogene Proteins, met; c Met Receptor Tyrosine Kinase; c met Proteins; met Proto Oncogene Proteins; HGF Receptor; Hepatocyte Growth Factor Receptor; c-met Proteins; met Proto-Oncogene Proteins

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        Proto-Oncogene Proteins c-met: 723
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        Proto-Oncogene Proteins c-met: 723
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Proto-Oncogene Proteins c-met: 723
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        Proto-Oncogene Proteins c-met: 723
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7896
      - Proto-Oncogene Proteins: 7
        Proto-Oncogene Proteins c-met: 723

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Drug/Important Bio-Agent (IBA)